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  • Title: Simultaneous derivative spectrophotometric determination of aztreonam and L-arginine in injections.
    Author: Morelli B.
    Journal: J Pharm Sci; 1990 Mar; 79(3):261-5. PubMed ID: 2338637.
    Abstract:
    Mixtures of aztreonam, 2S-[2 alpha,3 beta(Z)]-2-[[[1-(2-amino-4-thiazolyl-2- [(2-methyl-4-oxo-1-sulfo-3-azetidinyl) amino]-2-oxo- ethylidine]amino]oxy]-2-methyl-propanoic acid, and L-arginine are assayed by peak-to-baseline, peak-to-peak, and zero-crossing second-derivative spectrophotometry. Aztreonam is the first of a new class of beta-lactam antibiotics (i.e., the mono-bactam antibiotics, highly effective against aerobic gram-negative bacteria). Beer's law is followed for up to 31 micrograms/mL of aztreonam and L-arginine in the presence of one another. Detection limits at the p = 0.05 level of significance range from 0.11 to 0.37 micrograms/mL. The method was successfully applied to laboratory mixtures and commercial injections containing these substances.
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