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  • Title: The wide-field optical sectioning of microlens array and structured illumination-based plane-projection multiphoton microscopy.
    Author: Yu JY, Holland DB, Blake GA, Guo CL.
    Journal: Opt Express; 2013 Jan 28; 21(2):2097-109. PubMed ID: 23389190.
    Abstract:
    We present a theoretical investigation of an optical microscope design that achieves wide-field, multiphoton fluorescence microscopy with finer axial resolution than confocal microscopy. Our technique creates a thin plane of excitation light at the sample using height-staggered microlens arrays (HSMAs), wherein the height staggering of microlenses generate temporal focusing to suppress out-of-focus excitation, and the dense spacing of microlenses enables the implementation of structured illumination technique to eliminate residual out-of-focus signal. We use physical optics-based numerical simulations to demonstrate that our proposed technique can achieve diffraction-limited three-dimensional imaging through a simple optical design.
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