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  • Title: Aminocatalytic asymmetric exo-Diels-Alder reaction with methiodide salts of Mannich bases and 2,4-dienals to construct chiral spirocycles.
    Author: Zhang SJ, Zhang J, Zhou QQ, Dong L, Chen YC.
    Journal: Org Lett; 2013 Feb 15; 15(4):968-71. PubMed ID: 23391251.
    Abstract:
    An asymmetric exo-Diels-Alder reaction of α-methylene carbonyl compounds, generated in situ from stable methiodide salts of Mannich bases, with 2,4-dienals, has been developed through trienamine activation of a chiral secondary amine. A spectrum of spirocyclanes with high molecular complexity was efficiently constructed in moderate to excellent diastereo- and enantioselectivity.
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