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  • Title: Antigenic cross-reactivity of venoms obtained from snakes of genus Bothrops.
    Author: da Silva AM, Lima MR, Nishikawa AK, Brodskyn CI, dos Santos MC, Furtado MF, da Silva WD, Mota I.
    Journal: Toxicon; 1990; 28(2):181-8. PubMed ID: 2339434.
    Abstract:
    Antigenic cross-reactivity was studied among the components of venoms from nine species of the genus Bothrops using species-specific antivenoms. Sera titration by DOT-ELISA detected similar levels of antibody when either homologous or heterologous antigens were used. Transblotted antigens, after SDS-PAGE fractionation, were also revealed by homologous and heterologous antivenoms. Antigens with mol. wt greater than 30,000 seemed to be the most cross-reactive. Antigens of about 24,000 mol. wt were poorly immunogenic. Antigens between 14-18,000 mol. wt cross-reacted only with B. moojeni, B. jararacussu, B. neuwiedi and B. pradoi venoms. Neutralization of the lethality of B. jararaca venom was observed by homologous and heterologous antivenoms.
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