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  • Title: Vedolizumab for Crohn's disease.
    Author: Mosli MH, Feagan BG.
    Journal: Expert Opin Biol Ther; 2013 Mar; 13(3):455-63. PubMed ID: 23394379.
    Abstract:
    INTRODUCTION: Crohn's disease (CD) is a chronic inflammatory disorder of unknown aetiology. Currently, approved therapies that include prednisone, anti-metabolites and TNF antagonists, are often ineffective and frequently cause adverse effects. As a result, patients with CD can develop serious complications that adversely affect quality of life. Consequently, new treatment options are needed. AREAS COVERED: This review discusses the potential role of vedolizumab, a humanised monoclonal antibody that selectively blocks lymphocyte trafficking to the gut, for the treatment of CD. All randomised placebo-controlled trials that evaluated vedolizumab for the treatment of CD were reviewed and safety and efficacy data evaluated. EXPERT OPINION: Vedolizumab is an effective and well-tolerated drug that is an important advance for the treatment of CD.
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