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  • Title: [Protective effect of qingxin kaiqiao fang containing cerebrospinal fluid on PC12 cell injury induced by Abeta25-35].
    Author: Ye GH, Hu HY, Chen X, Wang WH, Zhang XY.
    Journal: Zhongguo Zhong Yao Za Zhi; 2012 Nov; 37(21):3271-4. PubMed ID: 23397728.
    Abstract:
    OBJECTIVE: To observe the protective effect of Qingxin Kaiqiao Fang containing cerebrospinal fluid on PC12 cell injury induced by Abeta25-35, in order to provide basis for clinical application of the formula. METHOD: Sprague Dawley rats were orally administration with Qingxin Kaiqiao Fang (7.9 g x kg(-1)) twice a day for 3.5 days to prepare Qingxin Kaiqiao Fang containing cerebrospinal fluid. The nerve cell injury model was established by PC12 cells and Abeta25-35 with the concentration of 10 micromol x L(-1). The expressions of Bax, Bcl-2 and Caspase-3 mRNA were detected by immunohistochemical method in the PC12 cells. RESULT: The Qingxin Kaiqiao Fang group showed a significant higher PC12 cell activity than the model group, with decrease in Bax mRNA and Caspase-3 mRNA expressions and increase in Bcl-2 mRNA expression. There was a significant difference from the model group (P < 0.05, P < 0.01). CONCLUSION: Qinxin Kaiqiao Fang shows a significant protective effect on Abeta25-35-induced nerve cell injury.
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