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  • Title: Effects of ultra-early stage hyperbaric oxygenation on the hind limb bone mineral density in rats after complete spinal cord transection.
    Author: Liu M, Wu X, Tong M.
    Journal: Undersea Hyperb Med; 2013; 40(1):15-22. PubMed ID: 23397864.
    Abstract:
    AIM: To study the effects of ultra-early stage hyperbaric oxygenation on the hind limb bone mineral density in rats after complete spinal cord transection. METHODS: 55 SD rats were randomly assigned into three groups: sham-operated group (Sham); complete spinal cord transection. (CSCT) group; and hyperbaric oxygenation (HBO2) group. Three hours after surgery, the HBO2 group started receiving hyperbaric oxygen therapy. Bone mineral density (BMD) of total femur, total tibia and their subregions in vitro was measured with dual-energy X-ray absorptiometry (DEXA). RESULTS: After the six-week treatment, BMD of total femur, BMD in regions1-2 at the distal femur, BMD in regions 6-7 at the proximal femur and BMD in regions 1-2 at the proximal tibia in vitro were markedly decreased in CSCT group at six weeks post-operation compared with that in the sham-operated group (p < 0.05-0.01). Also, in the HBO2 group, BMD value of total femur in vitro was significantly higher than that in CSCT group (p < 0.05). CONCLUSION: Ultra-early stage hyperbaric oxygenation alleviates the hind limb bone loss in femur bone in rats following complete spinal cord transection.
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