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  • Title: Predictive value of neonatal brain MRI on the neurodevelopmental outcome of preterm infants by 5 years of age.
    Author: Setänen S, Haataja L, Parkkola R, Lind A, Lehtonen L.
    Journal: Acta Paediatr; 2013 May; 102(5):492-7. PubMed ID: 23398524.
    Abstract:
    AIM: To study the prognostic value of MRI in preterm infants at term equivalent age for cognitive development at 5 years of age. METHODS: A total of 217 very low birth weight/very low gestational age infants who all received brain MRI at term equivalent age were categorized into 4 groups based on the brain MRI findings. Cognitive development was assessed at 5 years of chronological age by using a short form of Wechsler Preschool and Primary Scale of Intelligence - Revised. This information was combined with neurosensory diagnoses by 2 years of corrected age. RESULTS: Of all infants 31 (17.0%) had Full Scale Intelligence Quotient (FSIQ) <85, 14 (6.5%) had cerebral palsy and 4 (1.8%) had severe hearing impairment. A total of 41 (22.0%) infants had some neurodevelopmental impairment at 5 years of age. Considering cognitive outcome (FSIQ <85), the positive predictive value of several major MRI pathologies was 43.8%, and the negative predictive value of normal finding or minor pathologies was 92.0% and 85.7%, respectively. CONCLUSION: The MRI of the brain at term equivalent age may be valuable in predicting neurodevelopmental outcome in preterm infants by 5 years of age. The findings should always be interpreted alongside the clinical information of the infant. Furthermore, MRI should not replace a long-term clinical follow-up for very preterm infants.
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