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  • Title: Pericentric inversion of chromosom 12 [Inv (12) (p12q12)] associated with idiopathic azoospermia in one infertile Tunisian man.
    Author: Ghorbel M, Baklouti-Gargouri S, ElGhazel H, Zribi N, Ben Abdallah F, Cherif M, Fakhfakh F, Saad A, Ammar-Keskes L.
    Journal: Biochem Biophys Res Commun; 2013 Mar 15; 432(3):472-4. PubMed ID: 23399567.
    Abstract:
    Chromosome aberrations are found in 2-7% of couples with fertility problems and pericentric inversions are structural chromosomal abnormalities, potentially associated with infertility or multiple miscarriages. In this study, we report the first case of pericentric inversion of chromosome 12 associated with non-obstructive azoospermia. A karyogram revealed pericentric inversion of chromosome 12 with breakpoints at 12p12 and 12q12. Testicular histopathology confirmed the Sertoli cell-only syndrome.
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