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  • Title: [Report of experiences with fibrinolytic therapy of deep venous thrombosis of the legs].
    Author: Schweder R, Ebert G, Rinke W, Ketterer KP.
    Journal: Anaesthesiol Reanim; 1990; 15(2):81-5. PubMed ID: 2340058.
    Abstract:
    It is reported on the fibrinolytic therapy of thrombosis of the deep veins of the legs, the pelvis and the arms. This treatment was analysed in 18 patients who were treated between 1983 and 1986. The possible causes of the development of thrombosis, such as ovulation inhibiting drugs and the postoperative state, are mentioned. Fibrinolysis was performed with streptokinase (awelysin) and urokinase (ukidan). In 11 patients streptokinase infusions therapy in ultra-high doses was carried out. Within 6 hours and 30 minutes the patients got 9.500,000 units of streptokinase. The complications of the streptokinase treatment are discussed. According to the age of the phlebothrombosis and the control phlebography 2 groups of patients were formed. In the first group including thromboses lasting for 1-6 days, 7 patients showed a complete recanalisation. In the second group including thromboses lasting for 1-3 weeks, only 4 patients developed complete recanalisation. The remaining patients had only a partial recanalisation. The post-lysis effect is stressed. Streptokinase therapy with ultra-high doses has become the standard procedure of fibrinolysis treatment in our hospital.
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