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  • Title: Inhibition of nitric oxide synthesis potentiates hypoxic vasoconstriction in isolated rat lungs.
    Author: Robertson BE, Warren JB, Nye PC.
    Journal: Exp Physiol; 1990 Mar; 75(2):255-7. PubMed ID: 2340164.
    Abstract:
    We have investigated the influence of endogenous nitric oxide (NO) on the vascular resistance of isolated rat lungs by inhibiting its synthesis with the false substrate N-monomethyl-L-arginine (L-NMMA). When perfused with blood at constant flow the addition of L-NMMA (10(-3) M) did not affect pulmonary arterial pressure in hyperoxia but did increase the response to hypoxia (PO2 25-35 mmHg) by 2.5 +/- 0.2 fold (mean +/- S.E.M.). The effect of L-NMMA was reversed by 3 x 10(-3) M-L-arginine, the true substrate for NO synthesis. Thus NO is an important pulmonary vasodilator but hypoxic vasoconstriction does not result from a reduction of its background release.
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