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  • Title: Effect of sodium addition to non-ionic contrast media on cardiac contractile force. Perfusion of the isolated rabbit heart with iohexol and iopentol containing 0 to 154 mmol Na+/l added as NaCl.
    Author: Bååth L, Almén T, Oksendal A.
    Journal: Acta Radiol; 1990 Jan; 31(1):99-104. PubMed ID: 2340228.
    Abstract:
    Cardiac contractile force after adding NaCl to the non-ionic contrast media iohexol and iopentol was investigated in the isolated rabbit heart. Iodine concentrations of 150, 300 and 350 mg I/ml were used with sodium concentrations ranging from 0 to 154 mmol/l. From physiologic experiences of nutrient solutions it should follow that a sodium-free solution of a non-ionic contrast medium, which also has the lowest hypertonicity, should cause the smallest decrease in contractile force. However, a small amount of sodium added to the contrast medium solutions, in the range of 19.25 to 38.5 mmol/l, caused the least decrease in contractile force. The decrease in contractile force was significantly more pronounced when no sodium was added or when larger amounts of sodium were added. A small amount of sodium also decreases the risk of ventricular fibrillation. Thus there is a possibility that addition of sodium could reduce the adverse effects of cardioangiography.
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