These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Evaluation of catalytic activity of multiple forms of cytochrome P-450 in liver microsomes of Wistar rats by androstenedione metabolism].
    Author: Khatsenko OG, Guliaeva LF, Mishin VM, Liakhovich VV.
    Journal: Biokhimiia; 1990 Feb; 55(2):308-14. PubMed ID: 2340316.
    Abstract:
    The synthesis of androstenedione (AD) metabolites in liver microsomes of control and phenobarbital (PB)-induced male and female Wistar rats was studied. In liver microsomes of non-induced male rats the predominant formation of 16 alpha-hydroxyandrostenedione was observed, whereas in females the predominant form was the 7 alpha-metabolite. Induction of animals of both sexes with PB was accompanied by an increase in the 16 beta-hydroxylase activity. The dynamics of synthesis of other AD metabolites specifically produced by such cytochrome P-450 forms as P-450a, P-450h and P-450p was investigated. The specificity of metabolism of androstenedione by multiple forms of cytochrome P-450 is postulated.
    [Abstract] [Full Text] [Related] [New Search]