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  • Title: [Ceftriaxone or combined cefazolin-gentamicin for complicated urinary tract infections].
    Author: Landau Z, Feld S, Krupsky M.
    Journal: Harefuah; 1990 Feb 01; 118(3):152-3. PubMed ID: 2341068.
    Abstract:
    40 seriously ill patients with complicated urinary tract infections were randomly assigned to receive either a single daily dose of ceftriaxone or combined therapy with cefazolin and gentamicin administered every 8 hours. The groups were of equal size, similar in age (both averaged 75 years) and the sex ratio was about 1:1 in each group. 32.5% had proven bacteremia and the overall mortality was 17.5%. Both regimens were similarly effective in terms of mortality, duration of fever (3.0-3.1 days), and sterilization of the urine prior to discharge from hospital. However, the single daily dose of ceftriaxone was much more convenient to administer.
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