These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Nicotine modulates the long-lasting storage of fear memory.
    Author: Lima RH, Radiske A, Köhler CA, Gonzalez MC, Bevilaqua LR, Rossato JI, Medina JH, Cammarota M.
    Journal: Learn Mem; 2013 Feb 15; 20(3):120-4. PubMed ID: 23418390.
    Abstract:
    Late post-training activation of the ventral tegmental area (VTA)-hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated memories, maybe by regulating the activation state of VTA-hippocampus dopamine connections.
    [Abstract] [Full Text] [Related] [New Search]