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  • Title: Cytotoxic triterpenoid saponins from the stems of Gordonia longicarpa.
    Author: Tang J, Yu L, Fu H, Li C, Yang J, Zhou W, Chen X, Zhang D.
    Journal: Planta Med; 2013 Mar; 79(5):353-60. PubMed ID: 23424012.
    Abstract:
    Nine new triterpenoid saponins named longicarposides A-I (1-9), together with three known saponins (10-12), were isolated from the stems of Gordonia longicarpa. The structures of the saponins were elucidated by a combination of 1D and 2D NMR techniques, mass spectrometry, and chemical methods. They were characterized to be oleanane-type saponins with sugar moieties linked to C-3 of the aglycone. Cytotoxic activities of these saponins were evaluated against five human tumor cell lines (HCT-8, Bel-7402, BGC-823, A549, and A2780) by using the MTT in vitro assay. Compounds 5, 7, 8, 10, and 11 exhibited potent cytotoxic activity with IC50 values of 1.42-8.42 µM, while 6, 9, and 12 showed selective cytotoxic activity toward the tested cell lines.
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