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  • Title: Synthesis and biological evaluation of novel 1,2,3-triazolonucleotides.
    Author: Głowacka IE, Balzarini J, Wróblewski AE.
    Journal: Arch Pharm (Weinheim); 2013 Apr; 346(4):278-91. PubMed ID: 23427010.
    Abstract:
    A general procedure for the preparation of 1,2,3-triazole analogs of nucleosides from diethyl 2-azidoethoxymethyl- and 2-azidoethoxyethylphosphonates was elaborated. The application of microwave irradiation shortened the reaction time to 10 min in comparison to ca. 48 h when 1,3-dipolar cycloadditions were performed under standard conditions. All compounds were evaluated in vitro for inhibitory activity against a broad variety of DNA and RNA viruses. None of the compounds were antivirally active at subtoxic concentrations. Compound 17k exhibited moderate inhibitory effects on the proliferation of human T-lymphocyte cells (IC50=64 µM for CEM).
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