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  • Title: Oxidative stress and anti-oxidative defence in patients with age-related macular degeneration.
    Author: Uğurlu N, Aşık MD, Yülek F, Neselioglu S, Cagil N.
    Journal: Curr Eye Res; 2013 Apr; 38(4):497-502. PubMed ID: 23432778.
    Abstract:
    PURPOSE: To evaluate the oxidative stress status and anti-oxidative defence in patients with age-related macular degeneration (AMD). METHODS: A total of 22 patients diagnosed with AMD and 23 age-matched healthy controls were included in the present study. Serum levels of total oxidant status (TOS), total antioxidant status (TAS), total thiol status (TTS) and paraoxonase 1 (PON1) activity were investigated from samples. RESULTS: Significant increase in TOS levels were observed in sera of AMD patients (25.3 ± 12.8) compared to controls (15.0 ± 4.4). TTS (404.3 ± 55.3) and serum PON1 enzyme activities (163.0 ± 65.5) were significantly lower in AMD patients (594.0 ± 64.2) relative to control groups (252.8 ± 132.7). CONCLUSION: The results of the present study show that there is a significant increase in oxidative stress in AMD patients and significant decrease in antioxidant defence, in the total thiol level and in PON1 activity in AMD patients compared with controls. The increased oxidative stress and decreased antioxidant levels may have a synergistic role in AMD development.
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