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  • Title: Modulation of inflammatory bowel disease in a mouse model following infection with Trichinella spiralis.
    Author: Zhao Y, Liu MY, Wang XL, Liu XL, Yang Y, Zou HB, Sun SM, Yu L, Rosenthal B, Shi HN, Boireau P, Wu XP.
    Journal: Vet Parasitol; 2013 May 20; 194(2-4):211-6. PubMed ID: 23433604.
    Abstract:
    Infection of mice with Trichinella spiralis redirects the mucosal immune system from a Th1 to a protective Th2 response with a reduction in the severity of trinitrobenzesulfonic acid-induced colonic damage. T. spiralis infection induced IL-10 production in a dose-dependent manner in oxazolone (OXZ)-induced colitis. This phenomenon may be responsible for the lack of efficacy of T. spiralis in the treatment of OXZ-induced colitis. These results indicate that if the source of increased IL-10 production is identified and addressed, T. spiralis may alter the Th2 response.
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