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  • Title: Synthesis and cytotoxicity evaluation of oleanolic acid derivatives.
    Author: Hao J, Liu J, Wen X, Sun H.
    Journal: Bioorg Med Chem Lett; 2013 Apr 01; 23(7):2074-7. PubMed ID: 23434227.
    Abstract:
    Twelve derivatives of oleanolic acid (1) have been synthesized and evaluated for their inhibitory activities against the growth of prostate PC3, breast MCF-7, lung A549, and gastric BGC-823 cancer cells by MTT assays. Within these series of derivatives, compound 17 exhibited the most potent cytotoxicity against PC3 cell line (IC50=0.39 μM) and compound 28 displayed the best activity against A549 cell line (IC50=0.22 μM). SAR analysis indicates that H-donor substitution at C-3 position of oleanolic acid may be advantageous for improvement of cytotoxicity against PC3, A549 and MCF-7 cell lines.
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