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  • Title: [The role of heme in formation of the native structure of cytochrome P-450 LM2].
    Author: Uvarov VIu, Tret'iakov VE, Kuznetsova GP, Archakov AI.
    Journal: Biokhimiia; 1990 Jan; 55(1):126-33. PubMed ID: 2344452.
    Abstract:
    The role of heme in the formation of cytochrome P-450 native structure was investigated. It was shown that treatment of purified and membrane-bound hemoproteins with H2O2 results in the total destruction of heme. After incubation with hemine the apoprotein thus obtained forms a catalytically active cytochrome P-450. The efficiency of this process depends on the enzyme microenvironment. The membrane-bound apoprotein may be reconstituted by 70-80%, whereas the soluble one--by 50%. It is concluded that the observed differences may be accounted for by a greater stability of the membrane-bound protein structure.
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