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  • Title: Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor.
    Author: Schade UF.
    Journal: Circ Shock; 1990 Jun; 31(2):171-81. PubMed ID: 2344657.
    Abstract:
    Pentoxifylline (POF) was found to possess high protecting potential in murine endotoxin shock. POF was tested in endotoxic shock in normal, LPS-tolerant, LPS-hyperreactive, and D-galactosamine-sensitized mice. A dose of 50 mg/kg increased survival in normal and tolerant mice from 50% in LPS-controls to 90%, and in LPS-hypersensitized and D-galactosamine-sensitized mice from 20% in LPS-controls to 90%. POF did not interfere with the development of endotoxin tolerance. The protective effects of POF were dose-dependent and were observed, even when POF was given up to 4 h post endotoxin. POF was found to inhibit the appearance of TNF in serum of LPS-treated, D-galactosamine-sensitized mice and in the supernatants of LPS-stimulated, thioglycollate-induced mouse peritoneal macrophages.
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