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  • Title: Synthesis, cytotoxicity, and apoptosis induction study of antitumor dinuclear platinum(II) complexes.
    Author: Xu G, Gou S, Gao C.
    Journal: Arch Pharm (Weinheim); 2013 Apr; 346(4):308-13. PubMed ID: 23447402.
    Abstract:
    Five novel dinuclear platinum(II) complexes with a new chiral ligand, 3-(2-amino-cyclohexylamino)-propionic acid (HP), were designed, prepared and spectrally characterized. The in vitro cytotoxicities of these compounds were evaluated against the HepG-2, MCF-7, A549, and HCT-116 cell lines. The results indicated that all compounds showed cytotoxicity towards the HepG-2 cell line. Particularly, complex X5, which has SO 4₂₋ as a bridge, exhibited better cytotoxicity than carboplatin or oxaliplatin against all selected cell lines. Moreover, double dyeing flow cytometric resection indicated that the target compounds inhibited tumor cell growth by inducing apoptosis.
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