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  • Title: [Role of intracellular pH in the development of resistance of leukemic cells to antineoplastic drugs].
    Author: Shestova OL, Ogloblina TA, Litinskaia LL.
    Journal: Eksp Onkol; 1990; 12(3):61-2. PubMed ID: 2344828.
    Abstract:
    Intracellular pH (pHi) of mouse lymphoid leukemia P388 cells was measured at the wavelength of 518 and 570 nm of fluorescein: pHi of rubomycin-sensitive P388 cells was higher than pHi of the cells resistant to this antitumour antibiotic (6.98 +/- 0.04 and 6.63 +/- 0.03, respectively, P less than 0.001). The role of pHi is established during induction of the resistance of tumour cells to the antitumour drugs.
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