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  • Title: [A study of interleukin-10 gene polymorphisms in Miao, Dong and Buyi ethnics of Guizhou].
    Author: Wang CJ, Shan KR, He Y, Zhang T, Li Y, Wu CX, Zhang C, Guan ZZ.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2013 Feb; 30(1):116-20. PubMed ID: 23450495.
    Abstract:
    OBJECTIVE: To investigate allelic frequencies of interluekin-10 (IL-10) gene promoter in Miao, Dong and Buyi ethnics of Guizhou. METHODS: TaqMan MGB-based real-time PCR was used to determine the genotypes of IL-10 -819 and IL-10 -592 in 589 Miao, Dong and Buyi ethnics of Guizhou. RESULTS: The allelic frequency of IL-10 -819 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. Allelic frequencies of IL-10 -592 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. In Miao, Dong and Buyi ethnics, the distributions of genotype frequencies of IL-10 -819 and IL-10 -592 were statistically different from Han ethnics from Guizhou and Taiwan of China as well as South Koreans. CONCLUSION: There is a heterogeneity in the frequencies of polymorphisms of IL-10 promoter among different ethnic groups.
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