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  • Title: Synthesis and self-assembly of thermo/pH-responsive double hydrophilic brush-coil copolymer with poly(L-glutamic acid) side chains.
    Author: Tang Y, Liu L, Wu J, Duan J.
    Journal: J Colloid Interface Sci; 2013 May 01; 397():24-31. PubMed ID: 23452517.
    Abstract:
    We report on the synthesis and self-assembly behavior of a well-defined double hydrophilic brush-coil copolymer with poly(N-isopropylacrylamide)-b-poly(glycidly methacrylate) (PNIPAM-b-PGMA) as backbone and poly(L-glutamic acid) (PLGA) as brush. The PNIPAM-b-PGMA was firstly prepared by the sequential reversible addition-fragmentation chain transfer polymerization of N-isopropylacrylamide and glycidly methacrylate. The obtained diblock copolymer was reacted with ethylenediamine (EDA) yielding the aminated macroinitiator (PNIPAM-b-PGMA-EDA), which was then used to initiate ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxyanhydride (BLG-NCA) to give PNIPAM-b-(PGMA-g-PBLG) copolymer. After the deprotection of benzyl groups on PBLG, double hydrophilic brush-coil copolymer, PNIPAM-b-(PGMA-g-PLGA), was obtained. The thermo- and pH-responsive micellization behaviors of PNIPAM-b-(PGMA-g-PLGA) in aqueous solution were investigated by fluorescence spectroscopy, (1)H NMR, dynamic light scattering, scanning electron microscopy, and circular dichroism. It can self-assemble into PNIPAM-core micelles at pH 10 and elevated temperature and PLGA-core micelles at pH 4 and room temperature. Such brush-coil copolymers have the potential applications as biomedical and intelligent materials.
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