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  • Title: Suppression and regression of a transplanted tumor in the guinea pig colon mediated by Mycobacterium bovis, strain BCG.
    Author: Harmel RP, Zbar B, Rapp HJ.
    Journal: J Natl Cancer Inst; 1975 Feb; 54(2):515-7. PubMed ID: 234537.
    Abstract:
    The growth in the colon wall of a diethylnitrosamine-induced hepatocarcinoma was suppressed by BCG. Injection of BCG into established colon-wall tumors caused tumor regression. Successful therapy required a limited tumor burden. Guinea pigs in which growth of the neoplasm was suppressed at the site of BCG infection developed systemic tumor transplantation immunity.
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