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Title: The Saccharomyces cerevisiae RhoGAP Rgd1 is phosphorylated by the Aurora B like kinase Ipl1. Author: Vieillemard A, Prouzet-Mauléon V, Hugues M, Lefebvre F, Mitteau R, Claverol S, Bonneu M, Crouzet M, Doignon F, Thoraval D. Journal: Biochem Biophys Res Commun; 2013 Mar 29; 433(1):1-5. PubMed ID: 23454383. Abstract: Polarized growth of the yeast Saccharomyces cerevisiae depends on different biological processes and requires several signaling pathways. Signaling is mediated through a set of proteins, which include Rho3p and Rho4p GTPases. Although these two proteins are involved in the control of distinct aspects of polarized growth in yeast, they have a common regulator: the Rgd1 RhoGAP protein. Here we demonstrate that Rgd1p is phosphorylated by the Aurora B like kinase Ipl1 and we observe that loss of Ipl1 function leads to a new Rgd1p distribution in a small part of the cell population.[Abstract] [Full Text] [Related] [New Search]