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  • Title: The effect of platelet-activating factor on [14C]aminopyrine uptake by isolated guinea pig parietal cells.
    Author: Nogami M, Suko M, Miyamoto T.
    Journal: Biochem Biophys Res Commun; 1990 May 16; 168(3):1047-52. PubMed ID: 2346478.
    Abstract:
    C16- and C18- platelet-activating factor (PAF) at 10(-6) M enhanced the uptake of [14C]aminopyrine (AP) by isolated guinea pig parietal cells. This increase was inhibited by a PAF antagonist CV-6209. In a medium with a low calcium (Ca2+) concentration (2 uM), this increase was not observed, which indicates that the increase of AP uptake by PAF is dependent on extracellular Ca2+. PAF and lyso-PAF showed no effect on AP uptake in the presence of histamine or carbachol.
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