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  • Title: A transgenic animal with antiviral properties that might inhibit multiple stages of infection.
    Author: Jiang L, Zhao P, Cheng T, Sun Q, Peng Z, Dang Y, Wu X, Wang G, Jin S, Lin P, Xia Q.
    Journal: Antiviral Res; 2013 May; 98(2):171-3. PubMed ID: 23466668.
    Abstract:
    Bombyx mori nucleopolyhedrovirus (BmNPV) is the primary pathogen of silkworms, causing severe economic losses in sericulture. To create antiviral silkworm strains, we constructed a transgenic vector in which the dsRNA for five tandem BmNPV genes was controlled by the BmNPV hr3 enhancer and IE1 promoter. The antivirus gene Bmlipase-1 was driven by B. mori midgut-specific promoter P2. Transgenic strains (SW-H) were generated via embryo microinjection using the practical silkworm strain SW. After infection with a high dose of BmNPV, the survival rates of SW-H and non-transgenic SW were 64% and 13%, respectively. SW-H could be the first transgenic animal that is highly antiviral and that might inhibit the virus at multiple stages of infection.
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