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  • Title: [Application of the Oxford classification of IgA nephropathy to predict renal outcome].
    Author: Peng YH, Su Y, Zhao YJ, Lin CN, Sun GF, Li H, Yu Y, Huang QY, Ye W, Li XM, Li XW.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2013 Feb; 35(1):102-7. PubMed ID: 23469800.
    Abstract:
    OBJECTIVE: To validate the value of the Oxford classification of IgA nephropathy in predicting the renal outcome in Chinese population. METHODS: Retrospective study was done in patients with IgA nephropathy. All slides were re-assessed according to the Oxford classification of IgA nephropathy. The primary end point is doubling serum creatinine, or a 50% reduction in estimated glomerular filtration rate (eGFR), or end-stage renal disease. Pathologic predictors for the progression to the end point were determined by univariate and multivariate Cox regression. RESULTS: Totally 533 patients were enrolled in the study. During the follow-up (median: 39 months; range: 12-263 months), 5.07% of the patients reached the end point. While tubular atrophy and interstitial fibrosis and arterial/ arteriolar lesion were associated with the endpoint in univariate analysis, only the T score was predictive of the renal outcome in multivariate Cox regression. Combination of the patho- logic lesions had no impact on renal outcome. CONCLUSION: According to the Oxford classification of IgA nephropathy, the degree of tubulointerstitial fibrosis is the only feature independently predictive of renal outcome.
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