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  • Title: Palladium-catalyzed multicomponent synthesis of 2-aryl-2-imidazolines from aryl halides and diamines.
    Author: Geden JV, Pancholi AK, Shipman M.
    Journal: J Org Chem; 2013 Apr 19; 78(8):4158-64. PubMed ID: 23472583.
    Abstract:
    An efficient palladium-catalyzed three-component reaction that combines aryl halides, isocyanides, and diamines provides access to 2-aryl-2-imidazolines in yields up to 96%. Through variation of the diamine component, the reaction can be extended to the synthesis of 2-aryl-1H-benzimidazoles and 2-aryl-1,4,5,6-tetrahydropyrimidines.
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