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  • Title: Complete form of pachydermoperiostosis: a case report.
    Author: Chander R, Kakkar S, Jain A, Barara M, Agarwal K, Varghese B.
    Journal: Dermatol Online J; 2013 Feb 15; 19(2):10. PubMed ID: 23473280.
    Abstract:
    Pachydermoperiostosis is a primary form of hypertrophic osteoarthropathy, which presents with pachydermia, digital clubbing, and radiologic periostosis. Pachydermoperiostosis occurs owing to mutations of the gene encoding for 15-hydroxyprostaglandin dehydrogenase (15HPGD). Clinical manifestations of PDP are thought to relate to excessive collagen formation and dysregulation of matrix proteins because of fibroblastic hyperactivation. We present a very rare case of the complete form of pachydermoperiostosis in a young Indian male.
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