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  • Title: Postmortem changes in brain catecholamine enzymes.
    Author: Black IB, Geen SC.
    Journal: Arch Neurol; 1975 Jan; 32(1):47-9. PubMed ID: 234734.
    Abstract:
    Postmortem changes in the activities of tyrosine hydroxylase, dopa decarboxylase, and dopamine-beta-hydroxylase were examined in various areas of rat brain. Tyrosine hydroxylase activity decreased in an exponential fashion with a half-time of two to four hours in caudate-putamen, substantia nigra, and locus ceruleus. Dopa decarboxylase activity remained within 20% of control values at five hours in these areas, but then decreased precipitously. Dopamine-beta-hydroxylase activity remained within 20% of control for at least 20 hours after death.
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