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  • Title: HBV-DNA, HBeAg/anti-HBe serological status in hepatitis B chronic individuals from central Italy.
    Author: Rapicetta M, di Nardo V, Rozera C, Marinucci G, Francisci D, Sarrecchia B, Ricci C, Albertoni F.
    Journal: Epidemiol Infect; 1990 Jun; 104(3):511-7. PubMed ID: 2347388.
    Abstract:
    A population of 488 HBsAg carrier individuals, from central Italy, classified on the basis of biochemical, clinical and histological parameters, was analysed for the presence of HBV-DNA in serum and its relationship with HBeAg/anti-HBe markers. The prevalence of HBV-DNA was 32.8% in chronic patients with biopsy-proven liver disease, and 20 and 4.3% respectively in asymptomatic carriers with and without altered ALT levels. The values in chronic patients were correlated with the histological activity. Concordance of HBV-DNA presence and HBeAg positivity was observed in only 61.4% of cases. However HBV-DNA prevalence in sera of anti-HBe positive individuals was very low in asymptomatic carriers with normal ALT levels (2.5%). Higher values were observed in anti-HBe positive chronic patients (15.8%) and in carriers occasionally found with changes in ALT without any other clinical sign of illness (16.7%). These data would indicate that HBV-DNA is the serological marker which is most closely related to liver disease.
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