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  • Title: Static and flow cytometric DNA analysis compared to histologic prognostic factors in a cohort of stage T2 breast cancer.
    Author: Arnerlöv C, Emdin SO, Roos G, Angström T, Bjersing L, Angquist KA, Jonsson H.
    Journal: Eur J Surg Oncol; 1990 Jun; 16(3):200-8. PubMed ID: 2347415.
    Abstract:
    DNA analysis with static and flow cytometry was performed on archival smears and tissue sections in 99 patients with T2 breast cancer (Stage II). Tumour size, histologic grade and axillary node metastases were significant prognostic predictors. Static cytometry revealed 63% aneuploid tumours, and ploidy was significantly correlated to histologic grade and survival. DNA measurements obtained by static and flow cytometry were strongly correlated. According to flow cytometry 53% of the tumours were aneuploid. Flow cytometric DNA analysis correlated to histologic grade and survival and gave prognostic information among the lymph-node negative patients. Ploidy seems to be a significant, although not an independent prognostic indicator for T2 breast cancer.
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