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  • Title: [Hormonal synergism, maturation of lung structure and surfactant production in the fetal sheep lung].
    Author: Schellenberg JC, Liggins GC.
    Journal: Gynakol Rundsch; 1990; 30(1):22-7. PubMed ID: 2347512.
    Abstract:
    Simultaneous administration of cortisol, triiodothyronine, and prolactin but not of any of these hormones infused singly or in combination of two, increases pulmonary distensibility and stability to term values in fetal sheep of 125 days gestation. Similar results are obtained with thyrotropin-releasing hormone and cortisol. Measurements of elastin and collagen and discrepancies between concentrations of alveolar surfactant and lung distensibility and stability suggest that maturation of connective tissue plays an important part in fetal lung maturation.
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