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  • Title: Proteomics imaging and the kidney.
    Author: Magni F, Lalowski M, Mainini V, Marchetti-Deschmann M, Chinello C, Urbani A, Baumann M.
    Journal: J Nephrol; 2013; 26(3):430-6. PubMed ID: 23475458.
    Abstract:
    Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are advanced technologies capable of revealing the spatial distribution of different molecules--e.g., drugs and their metabolites, endogenous lipids and complex peptides/proteins--directly in tissue specimens at the same time. Information obtained regarding tissues by MALDI profiling/imaging analysis can be correlated with other MS-based techniques, auxiliary imaging technologies and routine immunohistochemical stainings. In this review we describe the MALDI profiling/imaging technologies, providing examples of their application in kidney research.
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