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  • Title: Psychiatric disorders in first degree relatives of children and adolescents with obsessive compulsive disorder.
    Author: Lenane MC, Swedo SE, Leonard H, Pauls DL, Sceery W, Rapoport JL.
    Journal: J Am Acad Child Adolesc Psychiatry; 1990 May; 29(3):407-12. PubMed ID: 2347838.
    Abstract:
    One hundred and forty-five first-degree relatives (89 parents [96%] and 56 siblings [98%]) of 46 children and adolescents with severe primary obsessive compulsive disorder (OCD) were personally interviewed with clinical and structured psychiatric interviews. Parent interviews were scored by a rater blind to proband diagnosis. Thirty percent of probands had at least one first-degree relative with OCD: 25% of fathers and 9% of mothers received this diagnosis. Forty-five percent of fathers and 65% of mothers received one or more other psychiatric diagnoses. The increased familial rate of OCD over that expected from a general population, and over that found in parents of conduct disordered patients, is consistent with a genetic factor in OCD. Presenting obsessive compulsive symptoms of probands and their parents were usually dissimilar, arguing against any simple social or cultural transmission.
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