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  • Title: Total synthesis of (+)-pentamethylsalvianolic acid C.
    Author: Alford BL, Hügel HM.
    Journal: Org Biomol Chem; 2013 Apr 28; 11(16):2724-7. PubMed ID: 23478905.
    Abstract:
    The total synthesis of a methylated analogue of (+)-Salvianolic acid C has been achieved. Key aspects of the synthetic route include an economical Cu(I) acetylide coupling, unique carboxyl activation conditions via microwave irradiation and a novel lipase catalysed kinetic resolution of a racemic mixture of secondary alcohol Danshensu. The preparation of this methylated analogue will not only improve the bioavailability, but also enable access to new and wider bioactivity applications for (+)-Salvianolic acid C.
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