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  • Title: Association between polymorphisms in the renin-angiotensin system genes and prevalence of spontaneously aborted fetuses.
    Author: Jeon YJ, Kim JH, Lee BE, Rah H, Shin JE, Kang H, Choi DH, Yoon TK, Lee WS, Shim SH, Kim NK.
    Journal: Am J Reprod Immunol; 2013 Sep; 70(3):238-45. PubMed ID: 23480300.
    Abstract:
    PROBLEM: The renin-angiotensin system is associated with angiogenesis, tissue remodeling, prenatal development, and Th2 cytokine production. The purpose of this study was to evaluate whether polymorphisms in angiotensin I-converting enzyme [ACE insertion/deletion (I/D)], angiotensinogen (AGT M235T), and angiotensin II type 1 receptor (AT1R 1166A>C) affect the prevalence of spontaneously aborted fetuses (SAFs). METHOD OF STUDY: One hundred and ninety-eight SAFs were <20 weeks of gestational age. The control subjects were 103 healthy children and 640 adults collected from a convenience sample. Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the ACE I/D, AGT M235T, and AT1R 1166A>C genotypes. RESULTS: II/MM/AA, II/MT/AA, and II/TT/AC of ACE/AGT/AT1R were significantly different from controls. In particular, the statistical significance of the II/MM/AA genotype remained strong in chromosomally normal SAFs. CONCLUSION: Our data suggest that the II/MM/AA of ACE/AGT/AT1R is a possible predisposing factor for spontaneous abortion.
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