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  • Title: Lacrimal gland sparing IgG4-related disease in the orbit.
    Author: Khan TT, Halat SK, Al Hariri AB.
    Journal: Ocul Immunol Inflamm; 2013 Jun; 21(3):220-4. PubMed ID: 23480602.
    Abstract:
    PURPOSE: We report an unusual case of orbital IgG4-related disease and discuss the distinguishing characteristics of the ophthalmic disease subtype. DESIGN: Case report. METHODS: Literature review and case description. RESULTS: Although lacrimal gland involvement has always been reported and elevated serum IgG4 is commonly observed, our case demonstrated neither in light of biopsy-proven IgG4 orbital involvement. A course of systemic steroids resolved our patient's periorbital abnormalities. CONCLUSIONS: IgG4-related orbital disease mandates a high index of suspicion, and should be confirmed by tissue biopsy. Possible progression to MALT lymphoma necessitates close surveillance and may require repeat biopsy.
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