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  • Title: The assessment of acid-base disturbance in man by the use of carbon dioxide titration curves.
    Author: Stoker JB, Kappagoda CT, Snow HM, Linden RJ.
    Journal: Clin Sci Mol Med; 1975 Feb; 48(2):133-8. PubMed ID: 234820.
    Abstract:
    1. Carbon dioxide titration curves were determined in vivo in dog and man at various degrees of acute non-respiratory acidaemia and alkalaemia. 2. The slope of the CO2 titration curve (delta log Pco2/delta pH) was found to increase with the severity of the acute non-respiratory alkalaemia the slope (delta log Pco2/delta pH) tended towards unity. 3. A simple scheme based on the CO2 titration curves determined in vivo has been proposed for the assessment of acute acid-base disturbances in man. 4. Carbon dioxide titration curves were also determined in vivo in patients with chronic respiratory and non-respiratory acidaemia and it was found that these curves were not significantly different from those obtained in states of acute acid-base disturbances. It is therefore suggested that the scheme described in this paper is applicable to all acid-base disturbances.
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