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  • Title: Effect of ouabain on growth of skin explants in organotypic culture.
    Author: Penniyaynen VA, Kipenko AV, Lopatina EV, Krylov BV.
    Journal: Bull Exp Biol Med; 2013 Feb; 154(4):419-20. PubMed ID: 23486569.
    Abstract:
    Organotypic culture was used to study the effects of glycoside ouabain and its aglycone ouaba-genin on the growth of skin explants from 10-12-day chicken embryos. The tested agents demonstrated dose-dependent inhibition of skin growth. The effective concentrations imply that ouabain and ouabagenin mediate their inhibitory effect on the skin growth via interaction with α1-isoform of Na(+),K(+)-ATPase that plays mostly the role of ionic pump.
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