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  • Title: A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling-isomerization-condensation reaction.
    Author: Wang M, Tan C, He Q, Xie Y, Yang C.
    Journal: Org Biomol Chem; 2013 Apr 28; 11(16):2574-7. PubMed ID: 23487245.
    Abstract:
    A novel Pd/Cu catalyzed domino reaction for the synthesis of functionalized pyrrolo[1,2-b]pyridazines from readily accessible (hetero)aryl propargyl alcohols and 1-amino-2-bromopyrroles was developed. This cascade process involves a Sonogashira cross-coupling reaction, an isomerization and an intramolecular condensation.
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