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  • Title: Suzuki-Miyaura cross-coupling of potassium dioxolanylethyltrifluoroborate and aryl/heteroaryl chlorides.
    Author: Fleury-Brégeot N, Oehlrich D, Rombouts F, Molander GA.
    Journal: Org Lett; 2013 Apr 05; 15(7):1536-9. PubMed ID: 23489071.
    Abstract:
    A robust and efficient protocol for the introduction of the dioxolanylethyl moiety onto various aryl and heteroaryl halides has been developed, providing cross-coupling yields up to 93%. Copper-catalyzed borylation of 2-(2-bromoethyl)-1,3-dioxolane with bis(pinacolato)diboron followed by treatment with potassium bifluoride provides the key organotrifluoroborate reagent.
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