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  • Title: Bone marrow transplantation for chronic myelogenous leukemia. Results of the French Cooperative Group (GEGMO).
    Author: Devergie A, Reiffers J, Vernant JP, Cahn JY, Guyotat D, Maraninchi D, Rio B, Michallet M, Jouet JP, Milpied N.
    Journal: Nouv Rev Fr Hematol (1978); 1990; 32(1):86-9. PubMed ID: 2349085.
    Abstract:
    Data on 281 patients with chronic myelogenous leukemia who received bone marrow transplants were analyzed. The median follow-up time was 48 months. One hundred and seventy patients were in 1st chronic phase, 111 were in more advanced disease. The overall actuarial survival was 50% at 5 years. In multivariate analyses, the probability of relapse was correlated with the phase of the disease, the method of total body irradiation, the T cell depletion of the marrow and the occurrence of a chronic GVHD. The probability of disease free survival was significantly better for the patients who received a non T cell depleted marrow than for recipients of T cell depleted marrow. Bone marrow transplantion in first chronic phase with an HLA identical non T cell depleted marrow offers the better chance of prolonged leukemia free survival.
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