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  • Title: [The UV sensitivity of the bromodeoxyuridine-substituted chromosomes in the Chinese hamster].
    Author: Antoshchina MM, Luchnik NV.
    Journal: Radiobiologiia; 1990; 30(2):261-3. PubMed ID: 2349386.
    Abstract:
    Chinese hamster cells with chromosomes differently substituted for BUdR (TT-TT, TT-TB, TB-TB, TB-BB, where T is thymidine containing chromatid and B is BUdR substituted chromatid) were exposed to UV-light in phase G2 and chromosome aberrations (mainly chromatid breaks) were analysed. Breaks frequency per chromosome was proportional to BUdR content. No breaks were found in TT-TT chromosomes. The frequency of breaks per TB chromatid was similar with TT-TB and TB-BB chromosomes. In TB-BB chromosomes, however, virtually no breaks occurred in TB chromatids whereas in BB chromatids, their frequency was much higher than was expected.
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