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  • Title: [The radiosensitivity and thermoresistance of the cells of substrains of rhabdomyosarcoma RA-2 in rats].
    Author: Fedorova EV, Trusova VD, Vakhtin IuB.
    Journal: Radiobiologiia; 1990; 30(2):269-71. PubMed ID: 2349389.
    Abstract:
    The data obtained show that clonogenic RA-2T cells are 2-3 times more thermoresistant than clonogenic cells of the original thermosensitive RA-2T strain as estimated by D0 value upon heating up to 43-45 degrees C. After X-irradiation of rat rhabdomyosarcoma, a decrease in the capacity of forming pulmonary colonies is more pronounced in cells of the thermosensitive RA-2 strain cells than in those of the thermoresistant strain RA-2T (D0 = 1.6 Gy and D0 = 2.4 Gy, respectively). In all appearance, within one and the same tumor cell population, the hereditarily thermoresistant cells are more radioresistant than the thermosensitive ones.
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