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  • Title: [An evaluation of the effect of certain factors on the hemodynamics during anesthesia induction in stomach cancer patients].
    Author: Saltanov AI, Kadyrova EG, Lunevskiĭ VI, Remez VF, Goloskov NP.
    Journal: Anesteziol Reanimatol; 1990; (1):3-6. PubMed ID: 2350042.
    Abstract:
    Hemodynamic response to induction to anesthesia and tracheal intubation was assessed in 132 patients with gastric cancer divided into groups depending on the method of induction. Group I was administered thiopental sodium at a dose of 4-5 mg/kg, group II--thiopental sodium at the same dose and fentanyl (1.5 micrograms/kg), group III--thiopental sodium at the same dose with local laryngeal anesthesia using a 10% lidocaine solution, group IV--propanidid (4-5 micrograms/kg), and fentanyl (1.5 micrograms/kg), group V--thiopental sodium at the same dose and fentanyl (3-5 micrograms/kg), group VI--diazepam (15-20 mg) and fentanyl (3-5 micrograms/kg). Tracheal intubation followed dithylin injection without premedication. It has been established that adequate analgesia achieved by fentanyl (3-5 micrograms/kg) administration is the main factor that has a stabilizing effect on circulation during induction to anesthesia involving tracheal intubation. Lower drug doses and local laryngeal anesthesia proved effective in less than one third of patients. Circulatory response to pressor-depressor induction factors depends significantly on the baseline cardiac output and BP values and to a lesser extent on circulating blood volume (CBV) deficiency. Preoperative volume expansion with 12-15 ml/kg infusions stabilizes circulation parameters even in the absence of CBV deficiency, which confirms the functional nature of hypovolemia in patients with gastric cancer.
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